Human connection is a precious commodity, one so elusive enough that it’s easy to get lost along the way when seeking it out. In A Real Pain, written and directed by Jesse Eisenberg, that plain truth plays out on a Holocaust tour of Poland attended by cousins David (Kieran Culkin) and Benji (Eisenberg) with the dual goals of honoring their recently departed grandmother and reviving their once close relationship. Eisenberg’s airtight screenplay homes in on the friction-friendly differences between the two: David is self-conscious, a touch anxious, and prefers to keep his head down, while Benji is a charismatic live wire whose emotions are so rawly present that he can’t help but express the most intense versions of them as they happen. When moving his characters through this country fraught with history, Eisenberg is a fine visual essayist, but it is the most intimate pieces of the storytelling where he absolutely thrives, depicting the little moments of grace that keep people moving through an existence that is too often made up of a conspiracy of heartache and wounding slights. For all the poignancy, A Real Pain is often terrifically funny, taking full advantage of the commanding, instinctual performance of Culkin playing against Eisenberg’s straight-man exasperation like a classic comedy team. Eisenberg’s film is a precise piece of work that snaps cleanly into place.